Therefore, the anti-inflammatory effects of TP-PLGA-Au@RGD/HA hydrogels on RA-FLS may occur via the regulation of the mTOR/phosphorylation p70S6 kinase (mTOR/p70S6K) signal pathway, which maintains in the abnormal activated state, resulting in high expression of anti-apoptosis genes and the subsequent impact on multiple downstream effector molecules (Wu et al., 2017; Feng and Qiu 2018). This evidence concerns the gene MTOR and rheumatoid arthritis.