TKT and neoplasm: After the nanoparticles were uptaken by tumor cells, Ce6 was lasered to generate intracellular ROS, meanwhile, TK linkage was disrupted and DOX/DOXY were released at the bone tumor site sustainably to accelerate the production of ROS, triggered ROS burst, therefore leading to the enhancement of tumor cell inhibition and apoptosis (Tong et al., 2020).