Studies also suggest the cooperation of the AEP elongation complex (AF4, AF5q31, ENL and p-TEFb) and DotCom in the activation and maintenance of aberrant gene expression, and is critical in MLLr cell transformation, providing a rationale for combinatory targeting of DOT1L and Menin, which targets MLL fusion to chromatin to eradicate leukemia cells (Kühn et al., 2016; Dafflon et al., 2017; Okuda et al., 2017; Olsen et al., 2022). The gene discussed is DOT1L; the disease is leukemia.