The GSDM protein family includes six members (GSDMD, GSDMA, GSDMB, GSDMC, GSDME (DFNA5), and DFNB59), which can be cleaved by cysteine protease caspase through a variety of ways, exposing its active N-terminus, and then, pores are formed on the cell membrane surface, causing cell swelling, thereby inducing cell pyroptosis and ultimately participating in the occurrence and development of inflammation and malignant tumors (Qiu et al., 2017). The gene discussed is GSDME; the disease is cancer.