In our study, we identified 14 differentially expressed lncRNAs (LINC01963, AL132989.1, AC060780.1, AL451085.2, AC098487.1, PTOV1-AS2, LINC00460, AC012467.2, LINC00958, CTBP1-DT, AC116914.2, AC103702.2, AL022328.2, and AL450992.2), which were chosen as independent prognosis factors of HNSCC patients. The gene discussed is PTOV1; the disease is head and neck squamous cell carcinoma.