Finally, to evaluate the clinical significance of gene expression regulated by m6A modification, clinical samples were selected to verify the candidate gene, and it was found that there were eight co-expressed genes, of which three were differential genes, namely, BCL11A, MATK, and CD300A. We also used univariate logistic regression, LASSO Cox regression, risk scores, and ROC to analyze these three genes and found that they were all potential m6A-regulated genes of asthma, and the risk scores in asthma were also higher than those in healthy controls. The gene discussed is MATK; the disease is asthma.