AGT and triple-A syndrome: It has also been demonstrated that, in an Ang II-induced abdominal aortic aneurysm (AAA) model, PM2.5 promotes AAA formation and induces an increase of AAA-related pathological changes, MMP2 and MCP-1 expression in human aortic smooth muscle cells (HASMCs), as the potential result of PM2.5-induced senescence and ROS accumulation (Jun et al., 2018).