In 369 samples with PD-L1 IHC data (Supplementary Figure S8), we found that the percentage of PD-L1 positive tumor cells had a moderate correlation (ρ = 0.65) with the mRNA level of PD-L1 (CD274) assessed by EdgeSeq PIP (Figure 5A), which was comparable to its association with RNA-seq (ρ = 0.69). The gene discussed is CD274; the disease is neoplasm.