The iCAF subtype is located more distant from tumor cells and showed an upregulation of leukemia inhibitory factor (LIF), C-X-C Motif Chemokine Ligand 1 (CXCL1), and Interleukin 6 (IL-6) and IL-11 (Öhlund et al., 2017). The gene discussed is CXCL1; the disease is neoplasm.