Intriguingly, we previously demonstrated in a neonatal mouse model that severe viral bronchiolitis is characterised by AEC necroptosis (Simpson et al., 2020) and, in the same mouse model, that the antagonism of RAGE attenuates the inflammatory response, lowers HMGB1 levels in the bronchoalveolar lavage and prevents the onset of type-2 inflammation and airway remodelling (Loh et al., 2020), although it remains to be determined whether this intervention decreased the extent of the necroptotic cell death. Here, HMGB1 is linked to bronchiolitis.