According to previous studies, HMGB3 can act as an oncogene that promotes tumor growth in gastric cancer (Fang et al., 2020), lung cancer (Xie et al., 2020), laryngeal squamous cell carcinoma (Yuan et al., 2021), bladder cancer (Xie et al., 2019) and glioblastoma (Liu et al., 2018). The gene discussed is HMGB3; the disease is lung cancer.