However, HMGB3 and HMGB4 were rarely reported in colorectal cancer (Zhang et al., 2017), so this study analyzed the expression and distribution of HMGB3 in colorectal cancer tissues and analyzed the relationship between HMGB3 gene transcripts and prognosis in conjunction with publicly available databases to explore the biological behavior of the new marker HMGB3 and its potential value for prognostic discrimination. Here, HMGB3 is linked to colorectal cancer.