Interestingly, the Parkinson’s disease KEGG pathway was downregulated in high αSyn cortical neurons vs high αSyn hESCs, due to the downregulation of several mitochondrial genes and cytochrome c oxidase genes, including NDUFB9, MT-CO2, MT-CO3, MT-ATP6, MT-ATP8, MT-CYB, COX7C, and CYCS. This may reflect a mitochondrial phenotype caused by elevated αSyn expression in cortical neurons. This evidence concerns the gene MT-CO3 and Parkinson disease.