Interestingly, FAM19A5 knockdown led to the reduction of TNF-α-induced anorexia and decreased loss of body weight, whereas administration of FAM19A5 by an intracerebroventricular route resulted in anorexia, body weight loss, hyperthermia, and the enhanced expression of inflammatory factors (Kang et al., 2020). Here, TNF is linked to Anorexia.