Further, TAFA4-null mice showed elevated hypersensitivity to mechanical and chemical stimuli, and excitability of spinal cord lamina IIi neurons in response to inflammation and nerve injury, whereas administration of recombinant TAFA4 in C57/Bl6 mice via an injection into the spinal canal was able to reverse carrageenan-induced mechanical hypersensitivity (Delfini et al., 2013). Here, TAFA4 is linked to injury.