More than 40 types of SCA have been identified and RGS8 was reported to be downregulated in mouse models of SCA1, SCA2, and SCA7 (Gatchel et al., 2008; Dansithong et al., 2015; Klockgether et al., 2019). The gene discussed is RGS8; the disease is autosomal dominant cerebellar ataxia.