Recently, RGS8 was shown to be associated with the pathology of several forms of spinocerebellar ataxia (SCA), an inherited disease associated with cerebellar degeneration (Gatchel et al., 2008; Dansithong et al., 2015; Wu and Kapfhammer, 2021b). Here, RGS8 is linked to autosomal dominant cerebellar ataxia.