ZFPM2 and cancer: For example, studies have demonstrated that dysregulation of lncRNA ZFPM2-AS1 is implicated in the initiation and development of a variety of malignant tumors; lncRNA ZFPM2-AS1 is located at the 8q23 region, an aggregate of cancer susceptibility loci, (Okamoto et al., 2003), and can act as an oncogene to promote HCC cell proliferation, invasion, and metastasis.