After adjustment for age at diagnosis, lymph node status, tumor size, chemotherapy, surgery, ER, PR and Triple Negative, a similar association was observed (58.3% vs. 48.7%, HR= 0.86, 95%CI= 0.67-1.11) but it was not significant (p-value= 0.25) (Table 2). Here, ESR1 is linked to neoplasm.