With the proposal of the tumor immune editing concept, a large number of studies have found that the tumor microenvironment may escape immune elimination by reducing antigenicity and immunogenicity, secreting inhibitory molecules such as tumor growth factor (TGF)-β and interleukin-10, and increasing the proportion of suppressor cell such as regulatory T cells and myeloid-derived suppressor cells (36). The gene discussed is TGFB1; the disease is neoplasm.