PGR and neoplasm: Previous studies have shown that the risk factors of meningiomas are complex, including age, sex, radiation, trauma, diabetes mellitus, and arterial hypertension (1, 7), and the progression of recurrent meningiomas involves numerous factors, including Simpson grade IV/V resection, a larger tumor size, tumor location, high vascular endothelial growth factor receptor (VEGFR) expression, WHO Grade II/III, high Ki-67 expression, and lack of progesterone receptor expression (10).