And in the fifth edition of the guidelines (WHO CNS5), glioblastoma, IDH-wildtype should be diagnosed in the setting of an IDH-wildtype diffuse and astrocytic glioma in adults if there is microvascular proliferation or necrosis or TERT promoter mutation or EGFR gene amplification or +7/-10 chromosome copy (8). This evidence concerns the gene IDH1 and glioblastoma.