Finally, to evaluate the risk and prognosis in pancreatic cancer more conveniently using pyroptosis-related genes, we constructed a prognostic model consisting of seven PRGs, including CASP4, GSDMC, NLRP1, PLCG1, IL-18, CASP1 and NLRP2. This evidence concerns the gene NLRP1 and familial pancreatic carcinoma.