BRCA1 and neoplasm: Moreover, we searched the reported driver gene data to screen out the known driver genes in the tumor sample based on Cancer Gene Census (http://cancer.sanger.ac.uk/census), MDG125 (23), SMG127 (24), CDG291 (25) database and we noticed that somatic mutations frequently found in this family, such as EGFR, BRCA1 and ROS1 were also observed (Table 2).