Then, with the development of high-throughput sequencing data, germline altered variants in other genes (MAST1, CENPE, LCT) (33–35) were identified to exhibit an essential role in the development of lung adenocarcinoma, and they were suspected to be related to the development of lung cancer through whole-exome or genome sequencing of samples from many lung cancer patients. The gene discussed is MAST1; the disease is lung adenocarcinoma.