Moreover, we searched the reported driver gene data to screen out the known driver genes in the tumor sample based on Cancer Gene Census (http://cancer.sanger.ac.uk/census), MDG125 (23), SMG127 (24), CDG291 (25) database and we noticed that somatic mutations frequently found in this family, such as EGFR, BRCA1 and ROS1 were also observed (Table 2). Here, ROS1 is linked to cancer.