ATR and lung adenocarcinoma: To our knowledge, this is the first such case report confirming the presence of c.7667C>G (p.T2556S), a germline ATR mutation, in a family with three occurrences of lung adenocarcinoma The resulting amino acid mutation, p.Thr2556Ser, was detected in the ATR’s conserved Phosphoinositide 3- and 4-kinase domain, which is involved in biological processes such as cell growth, proliferation, differentiation, motility, survival, and intracellular trafficking (43).