The results show that the expression of ISGF-3, TBP, MZF1, and SRF is significantly related to the survival of stomach cancer patients (ISGF-3: HR = 0.47, log-rank P = 1.1e-11; TBP: HR = 1.76, log-rank P = 5.5e-11; SRF: HR = 1.76, log-rank P = 5.5e-11; MZF1B: HR = 1.8, log-rank P = 1.7e-11). The gene discussed is SRF; the disease is gastric cancer.