Their results indicated that among patients with differentiated thyroid cancer with high serum thyroglobulin levels and negative radioiodine whole-body scan results, 99mTc-3PRGD2 SPECT showed higher sensitivity (96.6%) and positive predictive value (93.3%) for monitoring recurrence, while the probability of obtaining a positive SPECT finding was related to the thyroglobulin levels (p=0.006). Here, TG is linked to differentiated thyroid carcinoma.