COL18A1 and neoplasm: They concluded that since 99mTc-3PRGD2 SPECT imaging compares the lesion T/N value (uptake ratio of the tumor to that of the normal contralateral lung tissue) before and after treatment, as well as the changes in the difference between the T/N values, 99mTc-3PRGD2 SPECT has some clinical value in evaluating the efficacy of recombinant endostatin administration.