CDKN2A and Hepatosplenomegaly: Compared to patients with wild-type CDKN2A/B (Table 1), patients with CDKN2A/B deletions were significantly associated with older age (age >10 years; 30.6% vs. 15.2%, p < 0.001), a higher leukocyte count (median: 24.7 vs. 8.9×109/L, p < 0.001), a lower platelet count (median: 51 vs. 64 g/L, p = 0.049), and a higher percentage of hepatosplenomegaly (64.5% vs. 43.9%, p < 0.001).