Tau-PET data and dMRI data in Alzheimer’s disease were used to demonstrate the effectiveness of this method since there is a strong correlation between tau distribution and WM pathways (McAleese et al., 2017; Jacobs et al., 2018; Mito et al., 2018; Bischof et al., 2019; Wen et al., 2021). Here, MAPT is linked to Alzheimer disease.