Therefore, it is reasonable that dysregulation of the CRH may contribute to the pathophysiology of the major depressive disorders (MDD), as several works show (Aihara et al., 2007; Ishitobi et al., 2012; Menke, 2019) that that could be the scientific interpretation of the madness described by Hildegard of Bingen in her writings (Calef, 1997). This evidence concerns the gene CRH and major depressive disorder.