The R group showed only two differentially expressed genes across all study intervals: HLA-DRB5 and SMCR5. HLA-DRB5 encodes the major histocompatibility complex class II DRβ5, SMCR5 is the non-coding Smith-Magenis Syndrome Chromosome Region Candidate 5 gene. This evidence concerns the gene HLA-DRB5 and Smith-Magenis syndrome.