Indeed, the TNFα signaling pathway plays a pivotal role in cardiac inflammation development, as it amplifies inflammatory response to IFNγ via IFNγR upregulation and promotes adverse remodeling to HF with relevant consequence in the disease outcome (Crescioli et al., 2008; Sottili et al., 2009; Schumacher and Naga Prasad, 2018). This evidence concerns the gene TNF and hydrops fetalis.