We have previously reported on the pivotal role of the interferon (IFN)γ-induced 10-kDa protein (IP-10/CXCL10), a chemokine engaged in early stages of T helper 1 (Th1)-driven cardiac inflammation and disease development, including diabetic cardiomyopathy (DCM) (Di Luigi et al., 2016; Sottili et al., 2022). Here, CXCL10 is linked to familial dilated cardiomyopathy.