APOE and cerebral atherosclerosis: In the current study, WHHL rabbits aged 12 to 31 months exhibited a higher incidence of cerebral atherosclerosis (87%) and severe stenosis than apoE KO rabbits, suggesting that LDLs are more atherogenic than β-VLDLs in terms of cerebral atherosclerosis, which is consistent with the human imaging and pathological observations (7, 35, 36).