ApoE is a glycoprotein synthesized mainly in the liver and brain, which functions as a ligand of LDL receptors and lipoprotein receptor-related proteins for the clearance of chylomicrons and VLDL remnants, in addition to maintenance of the blood-brain barrier and regulation of brain inflammation and atherosclerosis (30–32). The gene discussed is LDLR; the disease is atherosclerosis.