APOE and cerebral atherosclerosis: Among 12 apoE KO rabbits fed a cholesterol diet, 3 (2 males and 1 female) exhibited cerebral atherosclerosis; two lesions were in the confluence of VA-BA and one was in the BA-PCA bifurcation, suggesting that cerebral atherosclerosis developed in these branches, although the incidence was markedly low (Figure 2).