In contrast to WT and apoE KO rabbits fed a cholesterol diet, 87% (13/15) of WHHL rabbits exhibited differing degrees of cerebral atherosclerosis in 3 major branches: PCA (43%), BA (73%) and VA (26%), but not in other branches (Figure 2), whereas two rabbits (aged 14 and 27 months) had no lesions. Here, APOE is linked to cerebral atherosclerosis.