DNMT1 and osteosarcoma: The quinoline derivative MC3343 specifically targets DNMT1, and we have recently demonstrated that this novel non-nucleoside DNMTi affects osteosarcoma cell proliferation, induces osteoblastic differentiation through specific re-expression of genes regulating this physiologic process and increased stable doxorubicin binding to DNA with fewer toxic effects on healthy cells than either 5-AZA or 5azadC (34).