Omega-3 supplementation increased serum total antioxidant capacity, decreased the structural changes of the hippocampus (diffuse vacuolar degeneration and distortion of the pyramidal cells), and decreased the expression of Cav1.2 (the voltage-dependent LTCC alpha 1c subunit) protein, and improved memory deficits.Thus, omega-3 could be useful neuroprotective agents against the cognitive impairment caused by hypothyroidism. This evidence concerns the gene CACNA1C and Cognitive impairment.