For group 1 (A-ROP and zone I ROP), no significant differences were observed between the two subgroups in terms of gestational age, birth weight, sex distribution, postmenstrual age at treatment and follow-up period (shown in Table 1).The comparison of treatment outcomes were shown in Table 2; the initial regression of anti-VEGF subgroup was significantly better than that of the laser subgroup (P < 0.001), and the reactivation rate and the probability of developing to retinal detachment were significantly lower than those of the laser subgroup (P < 0.001, P = 0.001, respectively). The gene discussed is VEGFA; the disease is retinal detachment.