The mean spherical refractive error of eyes (71 eyes/36 patients, 2 eyes had zone I ROP, 2 eyes had A-ROP, and the others had zone II ROP) treated with anti-VEGF agents was 1.20 ± 1.31 D; the mean astigmatism was 0.19 ± 1.51 D, and the mean spherical equivalent was 1.8 ± 1.99 D. The mean spherical refractive error of eyes (53 eyes/32 patients: 2 eyes had zone I ROP, and the others had zone II ROP) with laser therapy was 0.34 ± 1.16 D, and the mean astigmatism was −0.37 ± 1.62. Here, VEGFA is linked to Astigmatism.