In previous studies, scientists have demonstrated that low PAPP-A has been associated with poor placental invasion, resulting in placental insufficiency, intrauterine growth restriction, preeclampsia, stillbirth, abruption, and premature birth etc. Based on these findings, PAPP-A may play a significant role in regulating trophoblastic invasion (12, 14). This evidence concerns the gene PAPPA and preeclampsia.