AKT1 and cerebral infarction: Ligustilide, derived from Ligustilide walliichi, attenuates cerebral infarction, and reverses neurological injury, thereby affording neuroprotection, reverses apoptosis of hippocampal cells via activation of the PI3K/AKT pathway and consequently increases Bcl-2, and decreases Cyt C, Bax, and caspase-3 (101).