In addition, it may alter the motif of POU3F2, a transcription factor (TF) present in melanoma cell lines known to alter the expression of pigmentation genes (i.e. MITF, KITLG), although a recent study suggests that this TF does not have a role in normal skin melanocytes (Larue et al., 2010; Chitsazan et al., 2020). Here, POU3F2 is linked to melanoma.