TP53 and neoplasm: To test this speculation, we compared the survivorship curve of both the p53-wild (A549, MCF7) and the p53-null (H1299, SAOS2) tumor cell lines (Muller and Vousden, 2014; Tovar et al., 2006; Wachter et al., 2017), at a concentration gradient of pM1 and detected the downstream signaling of p53 following pM1 treatment by Western Blot and Q-PCR.