This diffusion is driven by ERK activation rather than typical mechanosensitive pathways such as YAP and TGFβ or myosin contraction.[79] In addition, an increase in matrix stiffness leads to an increase in cytoskeletal tension, which downregulates SOX4, a transcription factor maintaining the mesenchymal phenotype of breast cancer cells, and downstream mesenchymal marker expression, while the expression of other EMT‐related transcription factors (EMT‐TFs) remains unaffected. The gene discussed is TGFB1; the disease is breast cancer.