VIM and familial pancreatic carcinoma: Pancreatic cancer is also one of the hardest human solid cancers, with highly fibrotic and crosslinked ECM.[91] Tissue stiffening in pancreatic cancer tissues promoted the characteristics of EMT, including elevated vimentin expression, and decreases in E‐cadherin expression.[92] Growth factor signaling is combined with mechanical signaling in pancreatic cancer EMT.