TAMs could up‐regulate the synthesis and assembly of collagen types I, VI, and XIV in other cells in tumor region.[32] A subset of CD163/RELMα positive TAMs was also found to actuate stromal cell‐mediated collagen crosslinking, ECM stiffening, and tumor aggression.[33] Besides CAFs and TAMs, the role of other TME infiltrated cells, such as cancer‐associated adipocytes, in promoting the expression of fibronectin was gradually exposed.[34]. This evidence concerns the gene CD163 and neoplasm.