TGFB1 and breast carcinoma: This diffusion is driven by ERK activation rather than typical mechanosensitive pathways such as YAP and TGFβ or myosin contraction.[79] In addition, an increase in matrix stiffness leads to an increase in cytoskeletal tension, which downregulates SOX4, a transcription factor maintaining the mesenchymal phenotype of breast cancer cells, and downstream mesenchymal marker expression, while the expression of other EMT‐related transcription factors (EMT‐TFs) remains unaffected.