FN1 and neoplasm: One of the most significant differences between bone ECM and nonmineralized tissue is that bone ECM is approximately 105 to 106 times harder.[105] Matrix stiffness could promote EMT and further promote tumor cell invasion by regulating the nuclear translocation of cytoskeleton and MRTF‐A, as the epithelial marker E‐cadherin on the stiff matrix decreases and the mesenchymal markers Vimentin and Fibronectin increase.[106]