To determine whether TOP2A and RRM1 expression plays a role in tumour drug sensitivity, we measured the mRNA and protein levels of TOP2A and RRM1 in the bladder tumour cell lines BIU-87, KK47 and human embryonic bladder tissue derived cells CCC-HB-2 by RT-qPCR and Western blot analysis. This evidence concerns the gene TOP2A and urinary bladder neoplasm.