Notably, tumor-related signaling pathways such as PI3K, MYC, mTOR, and Wnt were significantly enriched in high-risk group, and continuous activation of these pathways have been demonstrated to be linked with HCC (Tian et al., 2021; Xia et al., 2021; Yi et al., 2021). The gene discussed is MYC; the disease is hepatocellular carcinoma.