The methylation analysis of the hub genes showed that 11 genes (ARHGAP27, CSNK2A1, ETV6, FNBP1L, KLF4, LTF, MGAM, MYO1F, NUCB2, RNF19B, and WWP3) were hypermethylated in IDD. Here, RNF19B is linked to intervertebral disk degenerative disorder.