LOXHD1 and hearing loss disorder: The proportions of different types of variation of LOXHD1 both worldwide and in China were shown in Supplementary Figure S2 and the results suggested that LOXHD1-associated hearing loss is caused firstly by missense variants and secondly by nonsense variants, which were consistent with the previous work that the majority of loss of function (LoF) variants in LOXHD1 are nonsense (Azaiez et al., 2018).