In relatively larger cohorts with more than 100 patients, the prevalence of LOXHD1-associated HL in United States HL patients was found to be 0.71% (8/1,119) (Sloan-Heggen et al., 2016), 1.5% in the Netherlands (3/200) (Zazo et al., 2017), and 0.97% in Italy (1/103) (Morgan et al., 2018). Here, LOXHD1 is linked to Hodgkins lymphoma.