In 2015, Mori et al. reported that patients with pathogenic variants in LOXHD1 are extremely rare in Japanese HL patients (0.15%, 2/1,314) while in 2019, Maekawa et al. identified 28 affected individuals with LOXHD1 variants among 8,074 Japanese HL patients (0.35%) (Maekawa et al., 2019). This evidence concerns the gene LOXHD1 and Hodgkins lymphoma.