Finally, through the intersection of the enriched core genes of the two pathways and the hub genes, we found that COL1A1, COL1A2, FN1, ITGA1, and ITGB1 were highly correlated with the ANXA1 gene, and these genes were overexpressed in glioma compared to normal brain tissues, which was verified in small samples of gliomas by the qPCR experiment. The gene discussed is COL1A2; the disease is central nervous system cancer.