Several families in the BIC database with evidence of genetic linkage indicate that the BRCA2 R3052W variant is a pathogenic mutation with a high probability of future cancer risk (Farrugia et al., 2008;Gomez Garcia et al., 2009;Mohammadi et al., 2009;Capanu et al., 2011;Cunningham et al., 2014). This evidence concerns the gene BRCA2 and cancer.