BReast CAncer Susceptibility Gene 2 (BRCA2), identified in the early 1990s, is a hereditary breast and ovarian cancer gene which codes for a 3,418 amino acid protein with several identifiable functional and structural domains and numerous interacting partners (Wooster et al., 1994; Wooster et al., 1995; Easton et al., 1997) (Figure 1A and reviewed in the work of Jimenez-Sainz and Jensen, 2021). The gene discussed is BRCA2; the disease is ovarian cancer.