GTF2F2 is correlated with post-transcriptional modification in protein molecules, including METTL3 and YTHDC1. The abnormal expression of m6A-related proteins occurs in the nervous system, thereby affecting neuritogenesis, brain volume, learning and memory, memory formation and consolidation, and is implicated in the pathogenesis of depression (Zhang et al., 2022). This evidence concerns the gene GTF2F2 and major depressive disorder.