In the lungs, FSCN1 is directly recruited to mitochondria under metabolic stress conditions to stabilize mitochondrial actin filaments, thereby promoting mitochondrial oxidative phosphorylation by increasing the biogenesis of respiratory complex I. Similarly, FSCN1 promotes the metastatic colonization of lung cancer cells by enhancing metabolic stress resistance and mitochondrial oxidative phosphorylation 56. Here, FSCN1 is linked to lung cancer.