Additionally, miR-489 shares inverse correlation with lncRNA CHRF in colorectal cancer (CRC) tissues whereas the downregulation of miR-489 by lncRNA CHRF overexpression promotes the metastasis and EMT process of CRC cells through the TWIST1/EMT axis, which is partially consistent to our experimental results 37. The gene discussed is TWIST1; the disease is colorectal carcinoma.