Wu et al. have found that silica-induced lung fibrosis can be inhibited by miR-489 through targeting the myeloid differentiation factor 88 (Myd88) and Smad3, however, miR-489 has been demonstrated to be negatively regulated by lncRNA cardiac hypertrophy-related factor (CHRF) 8. Here, MYD88 is linked to pulmonary fibrosis.