More importantly, LPCAT3 and ABHD12, a gene encoding an integral membrane lysophosphatidylserine (lysoPS) lipase, synergistically regulate lysoPS and C20:4 PS content in the CNS (central nervous system), and lysoPS lipids may be bioactive metabolites in neuropathology associated with PHARC (polyneuropathy, hearing loss, cerebellar ataxia, retinitis pigmentosa, early-onset cataracts) 16. This evidence concerns the gene ABHD12 and aceruloplasminemia.