RHOA and esophageal squamous cell carcinoma: Recently, in vivo and in vitro studies on ESCC showed that DIM could reverse epithelial-mesenchymal transition (EMT) process via the modulation of aryl hydrocarbon receptor (AHR), and DIM could inhibit ESCC metastasis through repressing RhoA/ROCK1-mediated COX2/PGE2 pathway 10.