Recently, in vivo and in vitro studies on ESCC showed that DIM could reverse epithelial-mesenchymal transition (EMT) process via the modulation of aryl hydrocarbon receptor (AHR), and DIM could inhibit ESCC metastasis through repressing RhoA/ROCK1-mediated COX2/PGE2 pathway 10. This evidence concerns the gene ROCK1 and esophageal squamous cell carcinoma.