CTNNB1 and hepatocellular carcinoma: In this study, hot spot mutations of CTNNB1 have been detected at Ser33, Ser37, Thr41 and Ser45 by droplet digital polymerase chain reaction (ddPCR) using circulating tumor DNA (ctDNA) of patients with HCC, and their relationship with ATZ/BV treatment response and prognosis has been investigated.