To further confirm that activated Wnt/β-catenin pathway was responsible for the stimulation of cell proliferation under HK2 overexpressing in ovarian cancer cells, XAV939, an inhibitor of Wnt/β-catenin pathway23, was used to block the expression of β-catenin in OVCA433-HK2 and SKOV3-HK2 cells. This evidence concerns the gene HK2 and ovarian cancer.