RT-qPCR assay indicated that ORC6's mRNA expression in ccRCC cells (786-O, Caki-1, ACHN, A-498, OSRC-2) was significantly higher than HK-2 cells (Fig. 6A), and that compared with normal tissues, ORC6's mRNA expression in ccRCC tumor tissues was also higher (13 cases of 15 cases were upregulated, Fig. 6B). This evidence concerns the gene ORC6 and neoplasm.